Publications

immunohistochemistry testing, ihc controls, ihc testing

Research matters

Because IHControls® and IHCalibrators are leading-edge technology, they have been the subject of extensive research, much of which is supported by the National Cancer Institute.  Many of the findings were published in prestigious journals in the field of histology and histopathology. Below is a listing of these publications.

immunohistochemistry publications, ihcontrols, ihc labs

Quantitative IHControls® Publications

K Vani, SR Sompuram, AK Schaedle, A Balasubramanian, M Pilichowska, S Naber, JD Goldsmith, KG Chang, F Noubary, & SA Bogen. 2017. The importance of epitope density in selecting a sensitive positive IHC control. J. Histochem. Cytochem. 65(8):463-477.

 

K Vani, SR Sompuram, AK Schaedle, A Balasubramanian, & SA Bogen. 2017. Analytic response curves of clinical breast cancer IHC tests. J. Histochem. Cytochem. 65(5):273-283.

 

K Vani, SR Sompuram, SP Naber, JD Goldsmith, R Fulton, & SA Bogen. 2016. Levey-Jennings analysis uncovers unsuspected causes of immunohistochemistry stain variability. Appl. Immunohistochem. Mol. Morphol. 24(10) 688-694.

 

SR Sompuram, K Vani, B Tracey, DA Kamstock, & SA Bogen. 2015. Standardizing immunohistochemistry: A new reference control for detecting staining problems. J. Histochem. Cytochem. 63:681-690.

 

SA Bogen, K Vani, & SR Sompuram. 2009. Molecular Mechanisms of Antigen Retrieval: Antigen Retrieval Reverses Steric Interference Caused By Formalin-Induced Crosslinks. Biotechnic & Histochem. 84(5):207-215.

 

SA Bogen, K Vani, B McGraw, V Federico, Iqbal Habib, R Zeheb, E Luther, C Tristram & SR Sompuram. Experimental Validation Of Peptide Immunohistochemistry Controls. 2009. Appl. Immunohistochem & Mol Morphol. 17(3):239-246.

 

Vani, K, SR Sompuram, P Fitzgibbons, & SA Bogen. 2008. National HER2 proficiency test results using standardized quantitative controls. Characterization of Laboratory Failures causes. Arch Pathol Lab Med. 132 (2):211-216.

 

Vani, K, SA Bogen, & S Sompuram. 2006. A high throughput combinatorial library technique for identifying formalin-sensitive epitopes. J Immunol Methods 317(1-2):80-89.

 

Sompuran SR, K Vani, & SA Bogen. 2006. A Molecular Model of Antigen Retrieval Using a Peptide Array. Am. J. Clin. Pathol. 125: 91-98

 

Sompuram SR, K Vani, LJ Hafer, & SA Bogen. 2006. Antibodies Immunoreactive With Formalin-Fixed Tissue Antigens Recognize Linear Protein Epitopes. Am. J. Clin. Pathol. 125: 82-90.

 

Sompuram, S, DM McMahon, K Vani, H Ramanathan, & SA Bogen. 2003. A Novel Microscope Slide Adhesive For Poorly Adherent Tissue Sections. 2003. J. Histotechnol. 26(2):117-123.

 

SA Bogen. A Root Cause Analysis Into The High Error Rate In Clinical Immunohistochemistry. App. Immunohistochem. Mol. Morphol. 2019. In press.

 

SR Sompuram, K Vani, AK Schaedle, A Balasubramanian, & SA Bogen. Selecting an optimal positive IHC control for verifying antigen retrieval. J. Histochem. Cytochem. 2019 67(4):275-289.

 

SR Sompuram, K Vani, AK Schaedle, A Balasubramanian, & SA Bogen. Quantitative assessment of immunohistochemistry laboratory performance by measuring analytic response curves and limits of detection.  Arch. Pathol. Lab. Med.2018 142(7):851-862.

 

Sompuram, S, K Vani, L Wei, H Ramanathan, Sarah Olken, & SA Bogen. 2004. A Water-Stable Protected Isocyanate Glass Array Substrate. Anal. Biochem. 326(1): 55-68.

 

Sompuram, S, K Vani, E Messana, & SA Bogen. 2004. A Molecular Mechanism of Formalin Fixation and Antigen Retrieval. Am. J. Clin. Pathol. 121(2): 190-199.

 

Sompuram, S, V Kodela, K Zhang, H Ramanathan, G Radcliffe, P Falb, & SA Bogen. 2002. A novel quality control slide for quantitative immunohistochemistry testing. J. Histochem. Cytochem. 50:1425-34.

 

Sompuram, S, V Kodela, H Ramanathan, C Wescott, G Radcliffe, & SA Bogen. 2002. Synthetic peptides identified from phage-displayed combinatorial libraries as immunodiagnostic assay surrogate quality control targets. Clinical Chemistry 48(3):410-420.