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IHCalibrators®

  • BCS IHCalibrators® make Calibration possible for IHC
    • 15 small round spots pre-printed on a microscope slide
    • The spots are glass microbeads covalently coated with a fluorescent biomarker
    • Each bead has a precise concentration of the biomarker traceable to a primary standard at NIST
    • The numbers provide an orientation to the sequence of increasing biomarker concentrations
    • A certificate of analysis provides the exact concentrations for each level
  • Identify the lowest concentration level that is still stained.
  • In each Panel, level 5 is the lowest that still has sufficient color intensity to consider positive.
  • Look at the Certificate of Analysis for that calibrator and correlate it with the actual concentration.
  • The actual Lower Limit of Detection (LOD) is likely at a concentration between levels 4 and 5.
  • METRIC calculates the precise LOD.
  • IHCalibrators® enable this graph
  • METRIC calculates LOD and dynamic range and establishes control ranges
  • Select an IHControl® within the dynamic range
  • Compare your LOD with other peer labs